HomePh.D. Study at IOCBTopics 2019Physical and Computational Chemistry

Physical and Computational Chemistry

Tutor Prof. RNDr. Petr Bouř, DSc.
Team

Petr Bouř

Topic Spectroscopic Studies of Protein Fibrils
Faculty FCHI VŠCHT, MFF UK
Abstract

Many biological processes involve aggregation of proteins into insoluble aggregates, "fibrils". Their properties are studied, for example, to find ways how to prevent neurodegenerative diseases. In our laboratory we use optical spectroscopic, computational and other methods to understand basic principles of fibril formation and structure. Particular aim of the thesis is to develop measurement and interpretation procedures for the modern spectroscopy of Raman optical activity, the topic involves spectroscopic experiments as well as computational modeling. 
 
Leading references:
1. Průša, J.; Bouř, P. Chirality 2018, 30, 55-64. “Transition dipole coupling modeling of optical activity enhancements in macromolecular protein systems.“
2. Kessler, J.; Yamamoto, S.; Bouř, P. Phys. Chem. Chem. Phys. 2017, 19, 13614-13621. “Establishing the link between fibril formation and Raman optical activity spectra of insulin.”