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Organic Chemistry

Tutor Dr. habil. Ullrich Jahn
Team

Ullrich Jahn

Topic Selective Oxidative Amino Acid and Peptide Modification
Faculty FCHT / FPBT VŠCHT, PřF UK
Abstract

Oxidative transformations of amino acids and proteins are normally unselective and lead to degradation. In this project selective oxygenation reactions of amino acids will be developed. The resulting products should have an excellent potential in C-C bond formation reactions with the aim to synthesize new non-natural amino acids. These results will be subsequently applied to the selective oxidative modification of oligopeptides. This may lead to metabolically stable biologically active products.