HomePh.D. Study at IOCBArchive - 2015Organic Chemistry

Organic Chemistry

Tutor Prof. Ing. Michal Hocek, CSc. DSc.
Team Michal Hocek
Topic Synthesis of novel hetero-fused 7-deazapurine nucleosides and nucleotides with potential biological activity or for modifications of DNA and RNA

Novel hetero-fused analogues of 7-deazapurine nucleosides and nucleotides will be designed and prepared for studying of their cytostatic and antiviral activity. Most of them will be based on new or scarcely studied heterocyclic systems, e.g. diverse isomers of thieno-, furo-, pyrido- or pyrimido-pyrrolo[2,3-d]pyrimidinů etc. In addition to testing of biological activity, selected nucleosides will be converted to NTPs and studied as potential inhibitors or substrates for polymerases in enzymatic synthesis of modified nucleic acids.

Leading references:
1. Tichý, M.; Pohl, R.; Tloušťová, E.; Weber, J.; Bahador, G.; Lee, Y.-J.; Hocek, M. "Synthesis and Biological Activity of Benzo-Fused 7-Deazaadenosine Analogues. 5- and 6-Substituted 4-Amino- or 4-Alkylpyrimido[4,5-b]indole Ribonucleosides" Bioorg. Med. Chem. 2013, 21, 5362-5372.
2. Nauš, P.; Caletková, O.; Konečný, P.; Džubák, P.; Bogdanová, K.; Kolář, M.; Vrbková, J.; Slavětínská, L.; Tloušťová, E.; Perlíková, P.; Hajdúch M.; Hocek, M. "Synthesis, cytostatic, antimicrobial and anti-HCV activity of 6-substituted 7-(het)aryl-7-deazapurine ribonucleosides" J. Med. Chem. 2014, 57, 1097-1110.