GSRC GSRC

Publications 2008

63. Kožíšek, M.; Svatoš, A.; Budešínský, M.; Muck, A.; Bauer, M.C.; Kotrba, P.; Ruml, T.; Havlas, Z.; Linse, S.; Rulíšek, L.: "Molecular design of specific metal-binding peptide sequences from protein fragments" Chemistry-Eur. J. 2008, 14, 7836-7846.
62. Cígler, P.; Král, V.; Kožíšek, M.; Konvalinka, J.; Mirsky, V.: "Anomalous adsorptive properties of HIV protease: Indication of two-dimensional crystallization?" Colloids and Surfaces B: Biointerfaces 2008, 64, 145-149.
61. Král, V.; Mader, P.; Collard, R.; Fábry, M.; Hořejší, M.; Řezáčová, P.; Kožíšek, M.; Závada, J.; Sedláček, J.; Rulíšek, M.; Brynda, J.: "Stabilization of antibody structure upon association to a human carbonic anhydrase IX epitope studied by X-ray crystallography, microcalorimetry, and molecular dynamics simulations" Proteins 2008, 71, 1275-1287.
60. Hoffman, H.E.; Jirásková, J.; Ingr, M.; Zvelebil, M.; Konvalinka, J.: "Recombinant human serine racemase: Enzymologic characterization and comparison with its mouse ortholog" Protein Expr Purif. 2008, 63, 62-67.
59. Grantz Šašková, K.; Kožíšek, M.; LepŠík, M.; Brynda, J.; Řezáčová, P.; Václavíková, J.; Kagan, R.; Machala, L.; Konvalinka, J.: "Enzymatic and Structural Analysis of the I47A Mutation Contributing to the Reduced Susceptibility to HIV Protease Inhibitor Lopinavir" Protein Sci. 2008, 17, 1555-1564.
58. Kožíšek, M.; Cígler, P.; LepŠík, M.; Fanfrlík, J.; Řezáčová, P.; Brynda, J.; Pokorná, J.; Plešek, J.; Gruner, B.; Grantz Šašková, K.; Václavíková, J.; Král, V.; Konvalinka, J.: "Inorganic Polyhedral Metallacarborane Inhibitors of HIV Protease: A New Approach to Overcoming, Antiviral Resistance" J. Med. Chem. 2008, 51, 4839-4843.
57. Kožíšek, M.; Grantz Šašková, K.; Řezáčová, P.; Maarseveen, N.; De Jong, D.; Boucher, C.A.; Kagan, R.M.; Nijhuis, M.N.; and Konvalinka, J.: "Ninety Nine is Not Enough: Molecular Characterization of Inhibitor Resistant HIV-1 Protease Mutants with Insertions in the Flap Region" J. Virol. 2008, 82, 5869-5878.
56. Wildová, M.; Hadravová, R.; Štokrová, J.; Křížová, I.; Ruml, T.; Hunter, E.; Pichová, I.; Rumlová, M.: "The effect of point mutations within the N-terminal domain of Mason-Pfizer monkey virus capsid protein on virus core assembly and infectivity" Virology 2008, 380, 157-163.
55. Gammon, D. B.; Snoeck, R.; Fiten, P.; Krečmerová, H.; Holý, A.; De Clercq, E.; Opdenakker, G.; Evans, D. H.; Andrei, G.: "Mechanism of antiviral drug resistance of vaccinia virus: Identification of residues in the viral DNA polymerase conferring differential resistance to anti-poxvirus drugs" J. Virol. 2008, 82, 12520-12534.
54. Renders, M.; Lievrouw, R.; Krečmerová, M.; Holý, A.; Herdewijn, P.: "Enzymatic polymerization of phosphonate nucleosides" ChemBioChem 2008, 9, 2883-2888.
53. Hari, Y.; Hwang, G. T.; Leconte, A. M.; Joubert, N.; Hocek, M.; Romesberg, F. E.: "Optimization of the Pyridyl Nucleobase Scaffold for Polymerase Recognition and Unnatural Base Pair Replication" ChemBioChem 2008, 9, 2796-2799.
52. Čerňa, I.; Pohl, R.; Klepetářová, B.; Hocek, M.: "Synthesis of 6,8,9-Tri- and 2,6,8,9-Tetrasubstituted Purines by a Combination of the Suzuki Cross-coupling, N-Arylation, and Direct C-H Arylation Reactions" J. Org. Chem. 2008, 73, 9048-9054.
51. Naesens, L.; Andrei, G.; Votruba, I.; Krečmerová, M.; Holý, A.; Neyts, J.; De Clercq, E.; Snoeck, R.: "Intracellular metabolism of the new antiviral compound, 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine" Biochem. Pharmacol. 2008, 76, 997-1005.
50. Cahová, H.; Pohl, R.; Bednárová, L.; Nováková, K.; Cvačka, J.; Hocek, M.: "Synthesis of 8-bromo-, 8-methyl- and 8-phenyl-dATP and their polymerase incorporation into DNA" Org. Biomol. Chem. 2008, 6, 3657-3660.
49. Kuchař, M.; Pohl, R.; Klepetářová, B.; Hocek, M.: "Synthesis of diverse 6-(1,2-disubstituted ethyl)purine bases and nucleosides via 6-(oxiran-2-yl)purines" Tetrahedron 2008, 64, 10355-10364.
48. Srnec, M.; Chalupský, J.; Fojta, M.; Zendlová, L.; Havran, L.; Hocek, M.; Kývala, M.; Rulíšek, M.: "Effect of Spin-Orbit Coupling on Reduction Potentials of Octahedral Ruthenium(II/III) and Osmium(II/III) Complexes" J. Am. Chem. Soc. 2008, 130, 10947-10954.
47. Vrábel, M.; Pohl, R.; Votruba, I.; Sajadi, M.; Kovalenko, S. A.; Ernsting, N. P.; Hocek, M.: "Synthesis and photophysical properties of 7-deaza-2'-deoxyadenosines bearing bipyridine ligands and their Ru(II)-complexes in position 7" Org. Biomol. Chem. 2008, 6, 2852-2860.
46. Nauš, P.; Kuchař, M.; Hocek, M.: "Cytostatic and activiral 6-arylpurine ribonucleosides IX. Synthesis and evaluation of 6-substituted 3-deazapurine ribonuclesides" Collect. Czech. Chem. Commun. 2008, 73, 665-678.
45. Dračínský, M.; Krečmerová, M.; Holý, A.: "Study of chemical stability of antivirally active 5-azacytosine acyclic nucleoside phosphonates using NMR spectroscopy" Bioorg. Med. Chem. 2008, 16, 6778-6782.
44. Hocek, M.; Fojta, M.: "Cross-coupling reactions of nucleoside triphosphates followed by polymerase incorporation. Construction and applications of base-functionalized nucleic acids" Org. Biomol. Chem. 2008, 6, 2233-2241.
43. Kuchař, M.; Pohl, R.; Klepetářová, B.; Votruba, I.; Hocek, M.: "Synthesis of substituted 6-cyclopropylpurine bases and nucleosides by cross-coupling reactions or cyclopropanations" Org. Biomol. Chem. 2008, 6, 2377-2387.
42. Turek, P.; Hocek, M.; Pohl, R.; Klepetářová, B.; Kotora, M.: "Cobalt-Induced Synthesis of 6-(Pyridin-2-yl)purines by Microwave-Enhanced [2+2+2] Cyclotrimerization" Eur. J. Org. Chem. 2008, 3335-3343.
41. Joubert, N.; Urban, M.; Pohl, R.; Hocek, M.: "Modular Synthesis of 4-Aryl- and 4-Amino-Substituted Benzene C-2'-Deoxyribonucleosides" Synthesis 2008, 1918-1932.
40. Bambuch, V.; Pohl, R.; Hocek, M.: "Synthesis of 6-(4,5-Dihydrofuran-2-yl)- and 6-(Tetrahydrofuran-2-yl)purine Bases and Nucleosides" Eur. J. Org. Chem. 2008, 2783-2788.
39. Bárta, J.; Pohl, R.; Klepetářová, B.; Ernsting, N. P.; Hocek, M.: "Modular Synthesis of 5-Substituted Thiophen-2-yl C-2'-Deoxyribonucleosides" J. Org. Chem. 2008, 73, 3798-3806.
38. Novák, P.; Číhalová, S.; Otmar, M.; Hocek, M.; Kotora, M.: "Co- and homocyclotrimerization reactions of protected 1-alkynyl-2-deoxyribofuranose. Synthesis of C-nucleosides, C-di- and C-trisaccharide analogues" Tetrahedron 2008, 64, 5200-5207.
37. Šilhár, P.; Hocek, M.; Pohl, R.; Votruba, I.; Shih, I.; Mabery, E.; Mackman, R.: "Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides" Bioorg. Med. Chem. 2008, 16, 2329-2366.
36. Štefko, M.; Pohl, R.; Klepetářová, B.; Hocek, M.: "A Modular Methodology for the Synthesis of 4- and 3-Substituted Benzene and Aniline C-Ribonucleosides" Eur. J. Org. Chem. 2008, 1689-1704.
35. Schinkmanová, M.; Votruba, I.; Shibata, R.; Han, B.; Liu, X.; Cihlar, T.; Holý, A.: "Human N6-Methyl-AMP/dAMP Aminohydrolase aminohydrolase (abacavir 5'-monophosphate deaminase) is capable of metabolizing N6-substituted purine acyclic nucleoside phosphonates" Collect. Czech. Chem. Commun. 2008, 73, 275-291.
34. Cahová, H.; Havran, L.; Brázdilová, P.; Pivoňková, H.; Pohl, R.; Fojta, M.; Hocek, M.: "Aminophenyl- and Nitrophenyl-Labeled Nucleoside Triphosphates: Synthesis, Enzymatic Incorporation, and Electrochemical Detection" Angew. Chem. Int. Ed. 2008, 47, 2059-2062.
33. Hasník, Z.; Šilhár, P.; Hocek, M.: "Hydroxymethylations of Aryl Halides by Pd-Catalyzed Cross-Couplings with (Benzoyloxy)methylzinc Iodide - Scope and Limitations of the Reaction" Synlett 2008, 543-546.
32. Pomeisl, K.; Holý, A.; Votruba, I.; Pohl, R.: "Syntheses of N3-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase" Bioorg. Med. Chem. Lett. 2008, 18, 1364-1367.
31. Rovenská, M.; Hlouchová, K.; Šácha, P.; Mlčochová, P.; Horák, V.; Zámečník, J.; Bařinka, C.; Konvalinka, J.: "Tissue expression and enzymologic characterization of human prostate specific membrane antigen and its rat and pig orthologs" Prostate 2008, 68, 171-182.
30. Bařinka, C.; Hlouchová, K.; Rovenská, M.; Majer, P.; Dauter, M.; Hin, N.; Ko, Y.-S.; Tsukamoto, T.; Slusher, B.S., Konvalinka, J.; Lubkowski, J.: "Structural Basis of Interactions between Human Glutamate Carboxypeptidase II and Its Substrate Analogs" J. Mol. Biol. 2008, 376, 1438-1450.
29. Hájek, M.; Votruba, I.; Holý, A.; Krečmerová, M.; Tloušťová, E.: "Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells" Biochem. Pharmacol. 2008, 75, 965-972.
28. Kuchař, M.; Hocek, M.; Pohl, R.; Votruba, I.; Shih, I.; Mabery, E.; Mackman, R.: "Synthesis, cytostatic, and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]-, and 6-[2-(dialkylamino)vinyl]purine nucleosides" Bioorg. Med. Chem. 2008, 16, 1400-1424.
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