GSRC GSRC

Publications

155. Mertlíková-Kaiserová, H.; Rumlová, M.; Tloušťová, E.; Procházková, E.; Holý, A.; Votruba, I.: "Point mutations in human guanylate kinase account for acquired resistance to anticancer nucleotide analogue PMEG" Biochem. Pharmacol. 2011, 82, 131-138.
154. Matoušová, M.; Votruba, I.; Otmar, M.; Tloušťová, E.; Günterová, J.; Mertlíková-Kaiserová, H.: "2´-Deoxy-5,6-dihydro-5-azacytidine - a less toxic alternative of 2´-deoxy-5-azacytidine: a comparative study of hypomethylating potential" Epigenetics 2011, 6, 769-776.
153. Jansa, P.; Baszczyňski, O.; Dračínský, M.; Votruba, I.; Zídek, Z.; Bahador, G.; Stepan, G.; Cihlar, T.; Mackman, R.; Holý, A.; Janeba, Z.: "A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities" Eur. J. Med. Chem. 2011, 46, 3748-3754.
152. Břehová, P.; Česnek, M.; Dračínský, M.; Holý, A.; Janeba, Z.: "The efficient synthesis of 2-arylpyrimidine acyclic nucleoside phosphonates using Liebeskind-Srogl cross-coupling reaction" Tetrahedron 2011, 67, 7379-7385.
151. Jansa, P.; Špaček, P.; Votruba, I.; Břehová, P.; Dračínský, M.; Klepetářová, B.; Janeba, Z.: "Efficient one-pot synthesis of polysubstituted 6-[(1H-1,2,3-triazol-1-yl)methyl]uracils through the "click" protocol" Collect. Czech. Chem. Commun. 2011, 76, 1121-1131.
150. Hocková, D.; Holý, A.; Andrei, G.; Snoeck, R.; Balzarini, J.: "Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: Efficient synthesis and antiviral activity" Bioorg. Med. Chem. 2011, 19, 4445-4453.
149. Jansa, P.; Holý, A.; Dračínský, M.; Baszczyňski, O.; Česnek, M.; Janeba, Z.: "Efficient and 'green' microwave-assisted synthesis of haloalkylphosphonates via the Michaelis-Arbuzov reaction" Green Chem. 2011, 13, 882-888.
148. Sedláček, O.; Břehová, P.; Pohl, R.; Holý, A.; Janeba, Z.: "The synthesis of the 8-C-substituted 2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine (PMEDAP) derivatives by diverse cross-coupling reactions" Can. J. Chem. 2011, 89, 488-498.
147. Baszczyňski, O.; Jansa, P.; Dračínský, M.; Klepetářová, B.; Holý, A.; Votruba, I.; De Clercq, E.; Balzarini, J.; Janeba, Z.: "Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines" Bioorg. Med. Chem. 2011, 19, 2114-2124.
146. Dračínský, M.; Jansa, P.; Ahonen, K.; Buděšínský, M.: "Tautomerism and the Protonation/Deprotonation of Isocytosine in Liquid- and Solid-States Studied by NMR Spectroscopy and Theoretical Calculations" Eur. J. Org. Chem. 2011, 8, 1544-1551.
145. Dračínský, M.; Jansa, P.; Chocholoušová, J.; Vacek, J.; Kovačková, S.; Holý, A.: "Mechanism of the isotopic exchange reaction of the 5-H hydrogen of uracil derivatives in water and nonprotic solvents" Eur. J. Org. Chem. 2011, 4, 777-785.
144. Čechová, L.; Jansa, P.; Šála, M.; Dračínský, M.; Holý, A.; Janeba, Z.: "The optimized microwave-assisted decomposition of formamides and its synthetic utility in the amination reactions of purines" Tetrahedron 2011, 67, 866-871.
143. Štefko, M.; Slavětínská, L.; Klepetářová, B.; Hocek, M.: "General and Modular Synthesis of Isomeric 5-Substituted Pyridin-2-yl and 6-Substituted Pyridin-3-yl C-Ribonucleosides Bearing Diverse Alkyl, Aryl, Hetaryl, Amino, Carbamoyl, and Hydroxy Groups" J. Org. Chem. 2011, 76, 6619-6635.
142. Standara, S.; Bouzková, K.; Straka, M.; Zacharová, Z.; Hocek, M.; Marek, J.; Marek, R.: "Interpretation of substituent effects on 13C and 15N NMR chemical shifts in 6-substituted purines" Phys. Chem. Chem. Phys. 2011, 13, 15854-15864.
141. Lund, T. J.; Cavanaugh, N. A.; Joubert, N.; Urban, M.; Patro, J. N.; Hocek, M.; Kuchta, R. D.: "B Family DNA Polymerases Asymmetrically Recognize Pyrimidines and Purines" Biochemistry 2011, 50, 7243-7250.
140. Nečas, D.; Hidasová, D.; Hocek, M.; Kotora, M.: "Modular synthesis of 1-α- and 1-β-(indol-2-yl)-2'-deoxyribose C-nucleosides" Org. Biomol. Chem. 2011, 9, 5934-5937.
139. Fojta, M.; Havran, L.; Pivoňková, H.; Horáková, P.; Hocek, M.: "Redox Labels and Indicators Based on Transition Metals and Organic Electroactive Moieties for Electrochemical Nucleic Acids Sensing" Curr. Org. Chem. 2011, 15, 2936-2949.
138. Bourderioux, A.; Nauš, P.; Perlíková, P.; Pohl, R.; Pichová, I.; Votruba, I.; Džubák, P.; Konečný, P.; Hajdúch, M.; Stray, K.M.; Wang, T.; Ray, A.S.; Feng, J.Y.; Birkus, G.; Cihlar, T.; Hocek, M.: "Synthesis and Significant Cytostatic Activity of 7-Hetaryl-7-deazaadenosines" J. Med. Chem. 2011, 54, 5498-5507.
137. Čerňová, M.; Čerňa, I.; Pohl, R.; Hocek, M.: "Regioselective Direct C-H Arylations of Protected Uracils. Synthesis of 5- and 6-Aryluracil Bases" J. Org. Chem. 2011, 76, 5309-5319.
136. Tichý, T.; Andrei, G.; Dračínský, M.; Holý, A.; Balzarini, J.; Snoeck, R.; Krečmerová, M.: "New prodrugs of Adefovir and Cidofovir" Bioorg. Med. Chem. 2011, 19, 3527-3539.
135. Topalis, D.; Lebeau, I.; Krečmerová, M.; Andrei, G.; Snoeck, R.: "Activity of different classes of acyclic nucleoside phosphonates against BK virus in primary human renal cells" Antimicrob. Agents Chemother. 2011, 55, 1961-1967.
134. Macíčková-Cahová, H.; Pohl, R.; Horáková, P.; Havran, L.; Špaček, J.; Fojta, M.; Hocek, M.: "Alkylsulfanylphenyl Derivatives of Cytosine and 7-Deazaadenine Nucleosides, Nucleotides and Nucleoside Triphosphates: Synthesis, Polymerase Incorporation to DNA and Electrochemical Study" Chem. Eur. J. 2011, 17, 5833-5841.
133. Kielkowski, P.; Pohl, R.; Hocek, M.: "Synthesis of Acetylene Linked Double-Nucleobase Nucleos(t)ide Building Blocks and Polymerase Construction of DNA Containing Cytosines in the Major Groove" J. Org. Chem. 2011, 76, 3457-3462.
132. Otmar, M; Dračínský, M.; Krečmerová, M.; Balzarini, J.; Andrei, G; Snoeck, R.: "Synthesis of O2- and N3-(2-Phosphonomethoxy)ethyl Derivatives of 6-Phenyl- and 6-Pyridinyl-5-azacytosine" Heterocycles 2011, 84, 797-813.
131. Horáková, P.; Macíčková-Cahová, H.; Pivoňková, H.; Špaček, J.; Havran, L.; Hocek, M.; Fojta, M.: "Tail-labelling of DNA probes using modified deoxynucleotide triphosphates and terminal deoxynucleotidyl tranferase. Application in electrochemical DNA hybridization and protein-DNA binding assays" Org. Biomol. Chem. 2011, 9, 1366 - 1371.
130. Macíčková-Cahová, H.; Pohl, R.; Hocek, M.: "Cleavage of Functionalized DNA Containing 5-Modified Pyrimidines by Type II Restriction Endonucleases" ChemBioChem 2011, 12, 431-438.
129. Mařák, D.; Otmar, M.; Votruba, I.; Dračínský, M.; Krečmerová, M.: "8-Aza-7,9-dideazaxanthine acyclic nucleoside phosphonate inhibitors of thymidine phosphorylase" Bioorg. Med. Chem. Lett. 2011, 21, 652-654.
128. Srnec, M.; Ryde, U.; Rulíšek, L.: "Reductive Cleavage of the O-O Bond in Multicopper Oxidases: QM/MM and QM Study" Faraday Discuss. 2011, 148, 41-53.
127. Perlíková, P.; P.; Pohl, R.; Votruba, I.; Shih, R.; Birkuš, G.; Cihlář, T.; Hocek, M.: "Phosphoramidate pronucleotides of cytostatic 6-aryl-7-deazapurine ribonucleosides" Bioorg. Med. Chem. 2011, 19, 229-242.
126. Zabransky, A.; Hoboth, P.; Hadravová, R.; Stokrova, J.; Sakalian, M.; Pichová, I.: "The noncanonical Gag domains p8 and n are critical for assembly and release of mouse mammary tumor virus" J. Virol. 2010, 84, 11555-11559.
125. Bohmová, K.; Hadravová, R.; Stokrova, J.; Tuma, R.; Ruml, T.; Pichová, I.; Rumlová, M.: "The effect of dimerizing domains and basic residues on in vitro and in vivo assembly of Mason-Pfizer monkey virus and Human immunodeficiency virus" J. Virol. 2010, 84, 1977-1988.
124. Beššeová, I.; Réblova, K.; Leontis, N. B.; Šponer, J.: "Molecular dynamics simulations suggest that RNA three-way junctions can act as flexible RNA structural elements in the ribosome" Nucleic Acids Res. 2010, 38, 6247-6264.
123. Pohl, R.; Rulíšek, L.; Rejman, D.: "The Stability and Reactivity of Activated Acryloylcarbamates as Reagents for the Synthesis of N-1 Substituted Thymine and Uracil - NMR and DFT Study" J. Phys. Org. Chem. 2010, published on-line: DOI 10.1002/poc.1775.
122. Vancoillie, S.; Chalupský, J.; Ryde, U.; Solomon, E. I.; Pierloot, K., Neese, F., Rulíšek, L.: "Multireference Ab Initio Calculations of g tensors for Trinuclear Copper Clusters in Multicopper Oxidases" J. Phys. Chem. B 2010, 114, 7692-7702.
121. Lepšík, M.; Srnec, M.; Plešek, J.; Buděšínský, M.; Klepetářová, B.; Hnyk, D.; Grüner, B.; Rulíšek, L.: "Thiocyanation of closo-Dodecaborate B12H122. A Novel Synthetic Route and Theoretical Elucidation of the Reaction Mechanism" Inorg. Chem. 2010, 49, 5040-5048.
120. Hoffman, H.E.; Jiraskova, J.; Zvelebil, M.; Konvalinka, J.: "Random mutagenesis of human serine racemase reveals residues important for the enzymatic activity" Collect. Czech. Chem. Commun. 2010, 5, 59-79.
119. Fanfrlik, J.; Bronowska, A.K.; Rezac, J.; Prenosil, O.; Konvalinka, J.; Hobza, P.: "A Reliable Docking/Scoring Scheme Based on the Semiempirical Quantum Mechanical PM6-DH2 Method Accurately Covering Dispersion and H-Bonding: HIV-1 Protease with 22 Ligands" J. Phys. Chem. B. 2010, 114, 12666-12678.
118. Opekar, S.; Turek, P.; Pohl, R.; Klepetářová, B.; Votruba, I.; Hocek, M.; Kotora, M.: "[2+2+2]-Cocyclotrimerization of 6-Alkynyl-7-benzylpurines with α,ω-Diynes" Heterocycles 2010, 82, 895-907.
117. Janeba, Z.; Holý, A.; Pohl, R.; Snoeck, R.; Andrei, G.; De Clercq, E.; Balzarini, J.: "Synthesis and biological evaluation of acyclic nucleotide analogues with a furo[2,3-d]pyrimidin-2(3H)-one base" Can. J. Chem. 2010, 88, 628-638.
116. Štefko, M.; Hocek, M.: "Synthesis of Phenol and Pyridone C-Ribo- and 2'-Deoxyribonucleosides by Palladium-Catalyzed Hydroxylations of Haloaryl C-Nucleosides" Synthesis 2010, 4199-4206.
115. Hájek, M.; Cvilink, V.; Votruba, I.; Holý, A.; Mertlíková-Kaiserová, H.: "Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP" Eur. J. Pharmacol. 2010, 643, 6-12.
114. Mertlíková-Kaiserová, H.; Votruba, I.; Matoušová, M.; Holý, A.; Hájek, M.: "Role of Caspases and CD95/Fas in the Apoptotic Effects of a Nucleotide Analog PMEG in CCRF-CEM Cells" Anticancer Res. 2010, 30, 2791-2798.
113. Krečmerová, M.; Holý, A.; Andrei, G.; Pomeisl, K.; Tichý, T.; Břehová, P.; Masojídková, M.; Dračínský, M.; Pohl, R.; Laflamme, G.; Naesens, L.; Hui, H.; Cihlar, T.; Neyts, J.; De Clercq, E.; Balzarini, J.; Snoeck, R.: "Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents" J. Med. Chem. 2010, 53, 6825-6837.
112. Bárta, J.; Slavětínská, L.; Klepetářová, B.; Hocek, M.: "Modular Synthesis of 5-Substituted Furan-2-yl C-2'-Deoxyribonucleosides and Biaryl Covalent Base-Pair Analogues" Eur. J. Org. Chem. 2010, 5432-5443.
111. Spáčilová, P.; Nauš, P.; Pohl, R.; Votruba, I.; Snášel, J.; Zábranská, H.; Pichová, I.; Ameral, R.; Birkuš, G.; Cihlář, T.; Hocek, M.: "CycloSal-phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases" ChemMedChem 2010, 5, 1386-1396.
110. Krečmerová, M.; Masojídková, M.; Holý, A.: "Acyclic nucleoside phosphonates with 5-azacytosine base moiety substituted in C-6 position" Bioorg. Med. Chem. 2010, 18, 387-395.
109. Kubelka, T.; Slavětínská, L.; Klepetářová, B.; Hocek, M.: "Synthesis of 2,4-Disubstituted Pyrimidin-5-yl C-2'-Deoxyribonucleosides by Sequential Regioselective Reactions of 2,4-Dichloropyrimidine Nucleosides" Eur. J. Org. Chem. 2010, 2666-2669.
108. Čerňa, I.; Pohl, R.; Klepetářová, B.; Hocek, M.: "Intramolecular Direct C-H Arylation Approach to Fused Purines. Synthesis of Purino[8,9-f]phenanthridines and 5,6-Dihydropurino[8,9-a]isoquinolines" J. Org. Chem. 2010, 75, 2302-2308.
107. Hasník, Z.; Pohl, R.; Hocek, M.: "Synthesis of (purin-6-yl)methylphosphonate bases and nucleosides" Tetrahedron Lett. 2010, 51, 2464-2466.
106. Raindlová, V; Pohl, R.; Šanda, M.; Hocek, M.: "Direct Polymerase Synthesis of Reactive Aldehyde-Functionalized DNA and Its Conjugation and Staining with Hydrazines" Angew. Chem. Int. Ed. 2010, 49, 1064-1066.
105. Macíčková-Cahová, H.; Vrábel, M.; Hocek, M.: "Cross-Coupling Modification of Nucleoside Triphosphates, PEX, and PCR Construction of Base-Modified DNA" Curr. Protoc. Chem Biol. 2010, 2, 1-14.
104. Ikonen, S.; Macíčková-Cahová, H.; Pohl, R.; Šanda, M.; Hocek, M.: "Synthesis of nucleoside and nucleotide conjugates of bile acids, and polymerase construction of bile acid-functionalized DNA" Org. Biomol. Chem. 2010, 8, 1194-1201.
103. Urban, M.; Joubert, N.; Purse, B.W.; Hocek, M.; Kuchta, R. D.: "Mechanisms by Which Human DNA Primase Chooses To Polymerize a Nucleoside Triphosphate" Biochemistry 2010, 49, 727-735.
102. Štefko, M.; Slavětínská, L.; Klepetářová, B.; Hocek, M.: "A General and Efficient Synthesis of Pyridin-2-yl C-Ribonucleosides Bearing Diverse Alkyl, Aryl, Amino, and Carbamoyl Groups in Position 6" J. Org. Chem. 2010, 75, 442-449.
101. Nauš, P.; Pohl, R.; Votruba, I.; Džubák, P.; Hajdúch, M.; Ameral, R.; Birkus, G.; Wang, T.; Ray, A.S.; Mackman, R.; Cihlar, T.; Hocek, M.: "6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents" J. Med. Chem. 2010, 53, 460-470.
100. Bobula, T.; Hocek, M.; Kotora, M.: "Sonogashira reactions of α- and β-1-ethynyl-2-deoxyribosides: synthesis of acetylene-extended C-nucleosides" Tetrahedron 2010, 66, 530-536.
99. Beššeová, I.; Otyepka, M.; Réblova, K.; Šponer, J.: "Dependence of A-RNA simulations on the choice of the force field and salt strength" Phys. Chem. Chem. Phys. 2009, 11, 10701-10711.
98. Pytelková, J.; Hubert, J.; Lepšík, M.; Šobotník, J.; Šindelka, R.; Křížková, I.; Horn, M.; Mareš, M.: "Digestive α-amylases of the flour moth Ephestia kuehniella - adaptation to alkaline environment and plant inhibitors" FEBS J. 2009, 276, 3531-3546.
97. Sehnal, P.; Stará, I. G.; Šaman, D.; Tichý, M.; Míšek, J.; Cvačka, J.; Rulíšek, L.; Chocholoušová, J.; Vacek, J.; Goryl, G; Szymonski, M.; Císařová, I.; Starý, I.: "An Organometallic Route to Long Helicenes" Proc. Natl. Acad. Sci. U. S. A. 2009, 106, 13169 13174.
96. Shroff, R.; Rulíšek, L.; Doubský, J.; Svatoš, A.: "Acid-Base-Driven Matrix-Assisted Mass Spectrometry for Targeted Metabolomics" Proc. Natl. Acad. Sci. U. S. A. 2009, 106, 10092-10096.
95. Vancoillie, S.; Rulíšek, L.; Neese, F.; Pierloot, K.: "Theoretical Description of the Structure and Magnetic Properties of Nitroxide-Cu(II)-Nitroxide Spin Triads by Means of Multiconfigurational Ab Initio Calculations" J. Phys. Chem. A 2009, 113, 6149-6157.
94. Vaněk, V.; Buděšínský, M.; Kabeleová, P.; Šanda, M.; Kožíšek, M.; Hančlová, I.; Mládková, J.; Brynda, J.; Rosenberg, I.; Koutmos, M.; Garrow, T.A.; Jiráček, J.: "Structure-Activity Study of New Inhibitors of Human Betaine-Homocysteine S-Methyltransferase" J. Med. Chem. 2009, 52, 3652-3665.
93. Hoffman, H.E.; Jirásková, J.; Ingr, M.; Zvelebil, M.; Konvalinka. J.: "Recombinant human serine racemase: Enzymologic characterization and comparison with its mouse ortholog" Protein Expr. Purif. 2009, 63, 62-67.
92. Mlčochová, P.; Bařinka, P.; Tykvart, J.; Šácha, P.; Konvalinka. J.: "Prostate-Specific Membrane Antigen and Its Truncated Form PSM´" The Prostate 2009, 69, 471-479.
91. Konvalinka, J.; Illnerová, H.; Hobza, P.; Hořejší, V.; Holý, A.; Jungwirth, P.; Pačes, V.; Martásek, P.; Zlatuška, J.: "Czech bibliometric system fosters mediocre research" Nature 2009, 460, 1079.
90. Hlouchová, K.; Barinka, C.; Konvalinka, J,; Lubkowski, J.: "Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III" FEBS J. 2009, 276, 4448-4462.
89. Grantz Šašková, K.; Kožíšek, M.; Řezáčová, P.; Brynda, J.; Yashina, T.; Kagan, R.K.; Konvalinka, J.: "Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir" J. Virol. 2009, 83, 8810-8818.
88. Heyda, J.; Pokorná, J.; Vrbka, L.; Vácha, R.; Jagoda-Cwiklik, B.; Konvalinka, J.; Jungwirth, P.; Vonrášek, J.: "Ion specific effects of sodium and potassium on the catalytic activity of HIV-1 protease" Phys. Chem. Chem. Phys. 2009, 11, 7599-7604.
87. Hoffman, H.E.; Jirásková, J.; Cígler, P.; Šanda, M.; Schraml, J.; Konvalinka, J.: "Hydroxamic Acids As a Novel Family of Serine Racemase Inhibitors: Mechanistic Analysis Reveals Different Modes of Interaction with the Pyridoxal-5´-phosphate Cofactor" J. Med. Chem. 2009, 52, 6032-6041.
86. Řezáčová, P.; Pokorná, J.; Brynda, J.; Kožíšek, M.; Cígler, P.; Lepšík, M.; Fanfrlík, J.; Řezáč, J.; Grantz Šašková, K.; Sieglová, I.; Plešek, J.; Šícha, V.; Grüner, B.; Oberwinkler, H.; Sedláček, J.; Kräusslich, H.-G.; Hobza, P.; Král, V.; Kovalinka, J.: "Design of HIV Protease Inhibitors Based on Inorganic Polyhedral Metallacarboranes" J. Med. Chem. 2009, 52, 7132-7141.
85. Macíčková-Cahová, H.; Hocek, M.: "Cleavage of adenine-modified functionalized DNA by type II restriction endonucleases" Nucleic Acids Res. 2009, 37, 7612-7622.
84. Štambaský, J.; Hocek, M.; Kočovský, P.: "C-Nucleosides: Synthetic Strategies and Biological Applications" Chem. Rev. 2009, 109, 6729-6764.
83. Doláková, P.; Dračínský, M.; Masojídková, M.; Šolínová, V.; Kašička, V.; Holý, A.: "Acyclic Nucleoside Bisphosphonates: Synthesis and Properties of Chiral 2-Amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines" Eur. J. Med. Chem. 2009, 44, 2408-2424.
82. Doláková, P.; Dračínský, M.; Fanfrlík, J.; Holý, A.: "Synthesis of Analogues of Acyclic Nucleoside Diphosphates Containing Phosphonomethylphosphinyl Moiety and Studies of Their Phosphorylation Reaction" Eur. J. Org. Chem. 2009, 7, 1082-1092.
81. Hocková, D.; Holý, A.; Masojídková, M.; Keough, D. T.; de Jersey, J.; Guddat, L. W.: "Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit /Plasmodium falciparum/ hypoxanthine-guanine-xanthine phosphoribosyltransferase" Bioorg. Med. Chem. 2009, 17, 6218-6232.
80. Keough, D. T.; Hocková, D.; Holý, A.; Naesens, L.; Skinner- Adamsm, T.; de Jersey, J.; Guddat, L. W.: "Inhibition of Hypoxanthine-Guanine Phosphoribosyltransferase by Acyclic Nucleoside Phosphonates: A New Class of Antimalarial Therapeutics" J. Med. Chem. 2009, 52, 4391-4399.
79. Urban, M.; Joubert, N.; Hocek, M.; Alexander, R. E.; Kuchta, R. D.: "Herpes Simplex Virus-1 DNA Primase: A Remarkably Inaccurate yet Selective Polymerase" Biochemistry 2009, 48, 10866-10881.
78. Pomeisl, K.; Holý, A.; Pohl, R.; Horská, K.: "Use of Pd-catalyzed Suzuki-Miyaura coupling reaction in the rapid synthesis of 5-aryl-6-(phosphonomethoxy)uracils and evaluation of their inhibitory effect towards human thymidine phosphorylase" Tetrahedron 2009, 65, 8486-8492.
77. Krečmerová, M.; Holý, A.: "Syntheses of antivirals from the family of acyclic nucleoside phosphonates and their prodrugs" PharmaChem 2009, 6-9.
76. Čerňová, M.; Pohl, R.; Hocek, M.: "Switching the Regioselectivity of Direct C-H Arylation of 1,3-Dimethyluracil" Eur. J. Org. Chem. 2009, 3698-3701.
75. Hasník, Z.; Pohl, R.; Klepetářová, B.; Hocek, M.: "Synthesis of (Purin-6-yl)acetates and Their Transformations to 6-(2-Hydroxyethyl)- and 6-(Carbamoylmethyl)purines" Collect. Czech. Chem. Commun. 2009, 74, 1035-3059.
74. Riedl, J.; Horáková, P.; Šebest, P.; Pohl, R.; Havran, L.; Fojta, M.; Hocek, M.: "Tetrathiafulvalene-Labelled Nucleosides and Nucleoside Triphosphates: Synthesis, Electrochemistry and the Scope of Their Polymerase Incorporation into DNA" Eur. J. Org. Chem. 2009, 3519-3525.
73. Štefko, M.; Pohl, R.; Hocek, M.: "Synthesis of benzamide-C-ribonucleosides by Pd-catalyzed aminocarbonylations" Tetrahedron 2009, 65, 4471-4483.
72. Klusák, V.; Bařinka, C.; Plechanovová, A.; Mlčochová, P.; Konvalinka, J.; Rulíšek, L.; Lubkowski, J.: "Reaction Mechanism of Glutamate Carboxypeptidase II Revealed by Mutagenesis, X-ray Crystallography, and Computational Methods" Biochemistry 2009, 48, 4126-4138.
71. Hřebabecký, H.; Dračínský, M.; De Palma, A. M.; Neyts, J.; Holý, A.: "Synthesis of novel carbocyclic nucleoside analogues derived from 7-oxabicyclo[2.2.1]heptane-2-methanol" Collect. Czech. Chem. Commun. 2009, 74, 487-502.
70. Hřebabecký, H.; Dračínský, M.; De Palma, A. M.; Neyts, J.; Holý, A.: "Synthesis of novel Racemic carbocyclic nucleoside analogues derived from 4,8-dioxatricyclo[4.2.1.03,7]nonane-9-methanol and 4-oxatricyclo[4.3.1.03,7]decane-10-methanol, compounds with activity against Coxsackie viruses" Collect. Czech. Chem. Commun. 2009, 74, 469-485.
69. Mlčochová, P.; Bařinka, C.; Tykvart, J.; Šácha, P.; Konvalinka, J.: "Prostate-Specific Membrane Antigen and Its Truncated Form PSM'" Prostate 2009, 69, 471-479.
68. Hasník, Z.; Pohl, R.; Klepetářová, B.; Hocek, M.: "Cross-Coupling Reactions of Halopurines with Aryl- and Alkyltrifluoro­borates; The Scope and Limitations in the Synthesis of Modified Purines" Synthesis 2009, 1309-1317.
67. Klečka, M.; Pohl, R.; Klepetářová, B.; Hocek, M.: "Direct C-H borylation and C-H arylation of pyrrolo[2,3-d]pyrimidines: synthesis of 6,8-disubstituted 7-deazapurines" Org. Biomol. Chem. 2009, 7, 866-868.
66. Vrábel, M.; Horáková, P.; Pivoňková, H.; Kalachova, L.; Černocká, H.; Cahová, H.; Pohl, R.; Šebest, P.; Havran, L.; Hocek, M.; Fojta, M.: "Base-Modified DNA Labeled by [Ru(bpy)3]2+ and [Os(bpy)3]2+ Complexes: Construction by Polymerase Incorporation of Modified Nucleoside Triphosphates, Electrochemical and Luminescent Properties, and Applications" Chem. Eur. J. 2009, 15, 1144-1154.
65. Kalachova, L.; Pohl, R.; Hocek, M.: "Synthesis of 2'-Deoxyuridine and 2'-Deoxycytidine Nucleosides Bearing Bipyridine and Terpyridine Ligands at Position 5" Synthesis 2009, 105-112.
64. Hoffman, H. E.; Jirásková, J.; Ingr, M.; Zvelebil, M.; Konvalinka, J.: "Recombinant human serine racemase: Enzymologic characterization and comparison with its mouse ortholog" Protein Expr Purif. 2009, 63, 62-67.
63. Kožíšek, M.; Svatoš, A.; Budešínský, M.; Muck, A.; Bauer, M.C.; Kotrba, P.; Ruml, T.; Havlas, Z.; Linse, S.; Rulíšek, L.: "Molecular design of specific metal-binding peptide sequences from protein fragments" Chemistry-Eur. J. 2008, 14, 7836-7846.
62. Cígler, P.; Král, V.; Kožíšek, M.; Konvalinka, J.; Mirsky, V.: "Anomalous adsorptive properties of HIV protease: Indication of two-dimensional crystallization?" Colloids and Surfaces B: Biointerfaces 2008, 64, 145-149.
61. Král, V.; Mader, P.; Collard, R.; Fábry, M.; Hořejší, M.; Řezáčová, P.; Kožíšek, M.; Závada, J.; Sedláček, J.; Rulíšek, M.; Brynda, J.: "Stabilization of antibody structure upon association to a human carbonic anhydrase IX epitope studied by X-ray crystallography, microcalorimetry, and molecular dynamics simulations" Proteins 2008, 71, 1275-1287.
60. Hoffman, H.E.; Jirásková, J.; Ingr, M.; Zvelebil, M.; Konvalinka, J.: "Recombinant human serine racemase: Enzymologic characterization and comparison with its mouse ortholog" Protein Expr Purif. 2008, 63, 62-67.
59. Grantz Šašková, K.; Kožíšek, M.; LepŠík, M.; Brynda, J.; Řezáčová, P.; Václavíková, J.; Kagan, R.; Machala, L.; Konvalinka, J.: "Enzymatic and Structural Analysis of the I47A Mutation Contributing to the Reduced Susceptibility to HIV Protease Inhibitor Lopinavir" Protein Sci. 2008, 17, 1555-1564.
58. Kožíšek, M.; Cígler, P.; LepŠík, M.; Fanfrlík, J.; Řezáčová, P.; Brynda, J.; Pokorná, J.; Plešek, J.; Gruner, B.; Grantz Šašková, K.; Václavíková, J.; Král, V.; Konvalinka, J.: "Inorganic Polyhedral Metallacarborane Inhibitors of HIV Protease: A New Approach to Overcoming, Antiviral Resistance" J. Med. Chem. 2008, 51, 4839-4843.
57. Kožíšek, M.; Grantz Šašková, K.; Řezáčová, P.; Maarseveen, N.; De Jong, D.; Boucher, C.A.; Kagan, R.M.; Nijhuis, M.N.; and Konvalinka, J.: "Ninety Nine is Not Enough: Molecular Characterization of Inhibitor Resistant HIV-1 Protease Mutants with Insertions in the Flap Region" J. Virol. 2008, 82, 5869-5878.
56. Wildová, M.; Hadravová, R.; Štokrová, J.; Křížová, I.; Ruml, T.; Hunter, E.; Pichová, I.; Rumlová, M.: "The effect of point mutations within the N-terminal domain of Mason-Pfizer monkey virus capsid protein on virus core assembly and infectivity" Virology 2008, 380, 157-163.
55. Gammon, D. B.; Snoeck, R.; Fiten, P.; Krečmerová, H.; Holý, A.; De Clercq, E.; Opdenakker, G.; Evans, D. H.; Andrei, G.: "Mechanism of antiviral drug resistance of vaccinia virus: Identification of residues in the viral DNA polymerase conferring differential resistance to anti-poxvirus drugs" J. Virol. 2008, 82, 12520-12534.
54. Renders, M.; Lievrouw, R.; Krečmerová, M.; Holý, A.; Herdewijn, P.: "Enzymatic polymerization of phosphonate nucleosides" ChemBioChem 2008, 9, 2883-2888.
53. Hari, Y.; Hwang, G. T.; Leconte, A. M.; Joubert, N.; Hocek, M.; Romesberg, F. E.: "Optimization of the Pyridyl Nucleobase Scaffold for Polymerase Recognition and Unnatural Base Pair Replication" ChemBioChem 2008, 9, 2796-2799.
52. Čerňa, I.; Pohl, R.; Klepetářová, B.; Hocek, M.: "Synthesis of 6,8,9-Tri- and 2,6,8,9-Tetrasubstituted Purines by a Combination of the Suzuki Cross-coupling, N-Arylation, and Direct C-H Arylation Reactions" J. Org. Chem. 2008, 73, 9048-9054.
51. Naesens, L.; Andrei, G.; Votruba, I.; Krečmerová, M.; Holý, A.; Neyts, J.; De Clercq, E.; Snoeck, R.: "Intracellular metabolism of the new antiviral compound, 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine" Biochem. Pharmacol. 2008, 76, 997-1005.
50. Cahová, H.; Pohl, R.; Bednárová, L.; Nováková, K.; Cvačka, J.; Hocek, M.: "Synthesis of 8-bromo-, 8-methyl- and 8-phenyl-dATP and their polymerase incorporation into DNA" Org. Biomol. Chem. 2008, 6, 3657-3660.
49. Kuchař, M.; Pohl, R.; Klepetářová, B.; Hocek, M.: "Synthesis of diverse 6-(1,2-disubstituted ethyl)purine bases and nucleosides via 6-(oxiran-2-yl)purines" Tetrahedron 2008, 64, 10355-10364.
48. Srnec, M.; Chalupský, J.; Fojta, M.; Zendlová, L.; Havran, L.; Hocek, M.; Kývala, M.; Rulíšek, M.: "Effect of Spin-Orbit Coupling on Reduction Potentials of Octahedral Ruthenium(II/III) and Osmium(II/III) Complexes" J. Am. Chem. Soc. 2008, 130, 10947-10954.
47. Vrábel, M.; Pohl, R.; Votruba, I.; Sajadi, M.; Kovalenko, S. A.; Ernsting, N. P.; Hocek, M.: "Synthesis and photophysical properties of 7-deaza-2'-deoxyadenosines bearing bipyridine ligands and their Ru(II)-complexes in position 7" Org. Biomol. Chem. 2008, 6, 2852-2860.
46. Nauš, P.; Kuchař, M.; Hocek, M.: "Cytostatic and activiral 6-arylpurine ribonucleosides IX. Synthesis and evaluation of 6-substituted 3-deazapurine ribonuclesides" Collect. Czech. Chem. Commun. 2008, 73, 665-678.
45. Dračínský, M.; Krečmerová, M.; Holý, A.: "Study of chemical stability of antivirally active 5-azacytosine acyclic nucleoside phosphonates using NMR spectroscopy" Bioorg. Med. Chem. 2008, 16, 6778-6782.
44. Hocek, M.; Fojta, M.: "Cross-coupling reactions of nucleoside triphosphates followed by polymerase incorporation. Construction and applications of base-functionalized nucleic acids" Org. Biomol. Chem. 2008, 6, 2233-2241.
43. Kuchař, M.; Pohl, R.; Klepetářová, B.; Votruba, I.; Hocek, M.: "Synthesis of substituted 6-cyclopropylpurine bases and nucleosides by cross-coupling reactions or cyclopropanations" Org. Biomol. Chem. 2008, 6, 2377-2387.
42. Turek, P.; Hocek, M.; Pohl, R.; Klepetářová, B.; Kotora, M.: "Cobalt-Induced Synthesis of 6-(Pyridin-2-yl)purines by Microwave-Enhanced [2+2+2] Cyclotrimerization" Eur. J. Org. Chem. 2008, 3335-3343.
41. Joubert, N.; Urban, M.; Pohl, R.; Hocek, M.: "Modular Synthesis of 4-Aryl- and 4-Amino-Substituted Benzene C-2'-Deoxyribonucleosides" Synthesis 2008, 1918-1932.
40. Bambuch, V.; Pohl, R.; Hocek, M.: "Synthesis of 6-(4,5-Dihydrofuran-2-yl)- and 6-(Tetrahydrofuran-2-yl)purine Bases and Nucleosides" Eur. J. Org. Chem. 2008, 2783-2788.
39. Bárta, J.; Pohl, R.; Klepetářová, B.; Ernsting, N. P.; Hocek, M.: "Modular Synthesis of 5-Substituted Thiophen-2-yl C-2'-Deoxyribonucleosides" J. Org. Chem. 2008, 73, 3798-3806.
38. Novák, P.; Číhalová, S.; Otmar, M.; Hocek, M.; Kotora, M.: "Co- and homocyclotrimerization reactions of protected 1-alkynyl-2-deoxyribofuranose. Synthesis of C-nucleosides, C-di- and C-trisaccharide analogues" Tetrahedron 2008, 64, 5200-5207.
37. Šilhár, P.; Hocek, M.; Pohl, R.; Votruba, I.; Shih, I.; Mabery, E.; Mackman, R.: "Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides" Bioorg. Med. Chem. 2008, 16, 2329-2366.
36. Štefko, M.; Pohl, R.; Klepetářová, B.; Hocek, M.: "A Modular Methodology for the Synthesis of 4- and 3-Substituted Benzene and Aniline C-Ribonucleosides" Eur. J. Org. Chem. 2008, 1689-1704.
35. Schinkmanová, M.; Votruba, I.; Shibata, R.; Han, B.; Liu, X.; Cihlar, T.; Holý, A.: "Human N6-Methyl-AMP/dAMP Aminohydrolase aminohydrolase (abacavir 5'-monophosphate deaminase) is capable of metabolizing N6-substituted purine acyclic nucleoside phosphonates" Collect. Czech. Chem. Commun. 2008, 73, 275-291.
34. Cahová, H.; Havran, L.; Brázdilová, P.; Pivoňková, H.; Pohl, R.; Fojta, M.; Hocek, M.: "Aminophenyl- and Nitrophenyl-Labeled Nucleoside Triphosphates: Synthesis, Enzymatic Incorporation, and Electrochemical Detection" Angew. Chem. Int. Ed. 2008, 47, 2059-2062.
33. Hasník, Z.; Šilhár, P.; Hocek, M.: "Hydroxymethylations of Aryl Halides by Pd-Catalyzed Cross-Couplings with (Benzoyloxy)methylzinc Iodide - Scope and Limitations of the Reaction" Synlett 2008, 543-546.
32. Pomeisl, K.; Holý, A.; Votruba, I.; Pohl, R.: "Syntheses of N3-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase" Bioorg. Med. Chem. Lett. 2008, 18, 1364-1367.
31. Rovenská, M.; Hlouchová, K.; Šácha, P.; Mlčochová, P.; Horák, V.; Zámečník, J.; Bařinka, C.; Konvalinka, J.: "Tissue expression and enzymologic characterization of human prostate specific membrane antigen and its rat and pig orthologs" Prostate 2008, 68, 171-182.
30. Bařinka, C.; Hlouchová, K.; Rovenská, M.; Majer, P.; Dauter, M.; Hin, N.; Ko, Y.-S.; Tsukamoto, T.; Slusher, B.S., Konvalinka, J.; Lubkowski, J.: "Structural Basis of Interactions between Human Glutamate Carboxypeptidase II and Its Substrate Analogs" J. Mol. Biol. 2008, 376, 1438-1450.
29. Hájek, M.; Votruba, I.; Holý, A.; Krečmerová, M.; Tloušťová, E.: "Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells" Biochem. Pharmacol. 2008, 75, 965-972.
28. Kuchař, M.; Hocek, M.; Pohl, R.; Votruba, I.; Shih, I.; Mabery, E.; Mackman, R.: "Synthesis, cytostatic, and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]-, and 6-[2-(dialkylamino)vinyl]purine nucleosides" Bioorg. Med. Chem. 2008, 16, 1400-1424.
27. Pomeisl, K.; Votruba, I.; Holý, A.; Pohl, R.: "Syntheses of Pyrimidine Acyclic Nucleoside Phosphonates as Potent Inhibitors of Thymidine Phosphorylase (PD-ECGF) from SD-lymphoma" Nucleosides, Nucleotides Nucleic Acids 2007, 26, 1025-1028.
26. Nencka, R.; Votruba, I.; Hřebabecký, H.; Jansa, P.; Tloušťová, E.; Horská, K.; Masojídková, H.; Holý, A.: "Discovery of 5-Substituted-6-chlorouracils as Efficient Inhibitors of Human Thymidine Phosphorylase" J. Med. Chem. 2007, 50, 6016-6023.
25. Vrbková, S.; Dračínský, M.; Holý, A.: "Bifunctional acyclic nucleoside phosphonates: 2. Symmetrical 2-{[bis(phosphono)methoxy]methyl}ethyl derivatives of purines and pyrimidines" Collect. Czech. Chem. Commun. 2007, 72, 965-983.
24. Duraffour, S.; Snoeck, R.; Krečmerová, M.; van Den Oord, K.; De Vos, R.; Holý, A.; Crance, J.-M.; Garin, D.; De Clercq. E.; Andrei, G.: "Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models" Antimicrob. Agents Chemother. 2007, 51, 4410-4419.
23. Krečmerová, M.; Holý, A.; Pohl, R.; Masojídková, M.; Andrei, G.; Naesens, L.; Neyts, J.; Balzarini, J.; De Clercq, E.; Snoeck, R.: "Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: Synthesis and antiviral activity" J. Med. Chem. 2007, 50, 5765-5772.
22. Brázdilová, P.; Vrábel, M.; Pohl, R.; Pivoňková, H.; Havran, L.; Hocek, M.; Fojta, M.: "Ferrocenylethynyl Derivatives of Nucleoside Triphosphates: Synthesis, Incorporation, Electrochemistry and Bioanalytical Applications" Chem. Eur. J. 2007, 13, 9527-9533.
21. Kožíšek, M.; Bray, J.; Řezáčová, P.; Šašková, K.; Brynda, J.; Pokorná, J.; Mammano, F.; Rulíšek, L.; Konvalinka, J.: "Molecular Analysis of the HIV-1 Resistance Development: Enzymatic Activities, Crystal Structures, and Thermodynamics of Nelfinavir-resistant HIV Protease Mutants" J. Mol. Biol. 2007, 374, 1005-1016.
20. Čerňa, I.; Pohl, R.; Hocek, M.: "The first direct C-H arylation of purine nucleosides" Chem. Commun. 2007, 4729-4730.
19. Krečmerová, M.; Holý, A.; Pískala, A.; Masojídková, M.; Andrei, G.; Naesens, L.; Neyts, J.; Balzarini, J.; De Clercq, E.; Snoeck, R.: "Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds" J. Med. Chem. 2007, 50, 1069-1077.
18. Renders, M.; Emmerechts, G.; Rozenski, J.; Krečmerová, M.; Holý, A.; Herdewijn, P.: "Enzymatic synthesis of phosphonomethyl oligonucleotides by therminator polymerase" Angew. Chem. Int. Ed. 2007, 46, 2501-2504.
17. Lebeau, I.; Andrei, G.; Krečmerová, M.; De Clercq, E.; Holý, A.; Snoeck, R.: "Inhibitory activity of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate SV 40 strains" Antimicrob. Agents Chemother. 2007, 51, 2268-2273.
16. Krečmerová, M.; Holý, A.; Masojídková, M.: "Pyrimidine Acyclic Nucleotide Analogues with Aromatic Substituents in C-5 Position" Collect. Czech. Chem. Commun. 2007, 72, 927-951.
15. Doláková, P.; Masojídková, M.; Holý, A.: "Efficient Synthesis of Pyrimidinecarbonitriles and Their Derivatives" Heterocycles 2007, 71, 1107-1115.
14. Vrbková, S.; Dračínský, M.; Holý, A.: "Bifunctional acyclic nucleoside phosphonates: synthesis of chiral 9-{3-hydroxy[1,4-bis(phosphonomethoxy)]butan-2-yl} derivatives of purines" Tetrahedron: Asymmetry 2007, 18, 2233-2247.
13. Mlčochová, P.; Plechanovová, A.; Bařinka, C.; Mahadeva, D.; Saldanha, C.; Rulíšek, L.; Konvalinka, J.: "Mapping of the active site of glutamate carboxypeptidase II by site-directed mutagenesis" FEBS J 2007, 274, 4731-4741.
12. Joubert, N.; Pohl, R.; Klepetářová, B.; Hocek, M.: "Modular and Practical Synthesis of 6-Substituted Pyridin-3-yl C-Nucleosides" J. Org. Chem. 2007, 72, 6797-6805.
11. Vrábel, M.; Pohl, R.; Klepetářová, B.; Votruba, I.; Hocek, M.: "Synthesis of 2'-deoxyadenosine nucleosides bearing bipyridine-type ligands and their Ru-complexes in position 8 through cross-coupling reactions" Org. Biomol. Chem. 2007, 5, 2849–2857.
10. Bařinka, C.; Rovenská, M.; Mlčochová, P.; Hlouchová, K.; Plechanovová, A.; Majer, P.; Tsukamoto, T.; Slusher, B. S.; Konvalinka, J.; Lubkowski, J.: "Structural Insight into the Pharmacophore Pocket of Human Glutamate Carboxypeptidase II" J. Med. Chem. 2007, 50, 3267-3273.
9. Hasník, Z.; Šilhár, P.; Hocek, M.: "Synthesis of (purin-6-yl)acetates and 6-(2-hydroxyethyl)purines via cross-couplings of 6-chloropurines with the Reformatsky reagent" Tetrahedron Lett. 2007, 48, 5589-5592.
8. Čapek, P.; Cahová, H.; Pohl, R.; Hocek, M.; Gloeckner, C.; Marx, A.: "An Efficient Method for the Construction of Functionalized DNA Bearing Amino Acid Groups through Cross-Coupling Reactions of Nucleoside Triphosphates Followed by Primer Extension or PCR" Chem. Eur. J. 2007, 13, 6196-6203.
7. Pomeisl, K.; Holý, A.; Pohl, R.: "Pd-catalyzed Suzuki-Miyaura coupling reactions in the synthesis of 5-aryl-1-[2-(phosphonomethoxy)ethyl]uracils as potencial multisubstrate inhibitors of thymidine phosphorylase" Tetrahedron Lett. 2007, 48, 3065-3067.
6. Hlouchová, K.; Bařinka, C.; Klusák, V.; Šácha, P.; Mlčochová, P.; Majer, P.; Rulíšek, L.; Konvalinka, J.: "Biochemical characterization of human glutamate carboxypeptidase III" J. Neurochem. 2007, 101, 682-696.
5. Zábranská, H.; Tůma, R.; Kluh, I.; Svatoš, A.; Ruml, T.; Hrabal, R.; Pichová, I.: "The Role of the S-S Bridge in Retroviral Protease Function and Virion Maturation" J. Mol. Biol. 2007, 365, 1493-1504.
4. Vrábel, M.; Hocek, M.; Havran, L.; Fojta, M.; Votruba, I.; Klepetářová, B.; Pohl, R.; Rulíšek, L.; Zendlová, L.; Hobza, P.; Shih, I.; Mabery, E.; Mackman, R.: "Purines Bearing Phenanthroline or Bipyridine Ligands and Their RuII Complexes in Position 8 as Model Compounds for Electrochemical DNA Labeling - Synthesis, Crystal Structure, Electrochemistry, Quantum Chemical Calculations, Cytostatic and Antiviral Activity" Eur. J. Inorg. Chem. 2007, 1752-1769.
3. Bařinka, C.; Starková, J.; Konvalinka, J.; Lubowski, J.: "A high-resolution structure of ligand-free human glutamate carboxypeptidase II" Acta Cryst. 2007, F63, 150-153.
2. Hocek, M.; Šilhár, P.; Pohl, R.: "Cytostatic and activiral 6-arylpurine ribonucleosides VIII. Synthesis and evaluation of 6-substituted purine 3'-deoxyribonucletides" Collect. Czech. Chem. Commun. 2006, 71, 1484-1496.
1. Kuchař, M.; Pohl, R.; Votruba, I.; Hocek, M.: "Synthesis of Purines Bearing Functionalized C-Substituents by the Conjugate Addition of Nucleophiles to 6-Vinylpurines and 6-Ethynylpurines" Eur. J. Org. Chem. 2006, 5083-5098.
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